BACKGROUND
The Midwest Defense Innovation Summit (MDIS) is the region’s premier gathering focused on advancing national security through mission-driven technology and capability development. Powered by the Applied Research Institute, this high-impact summit convenes senior defense leaders, policymakers, industry, academia, and regional partners to examine how emerging technologies are tested, transitioned, and fielded at speed in support of national defense priorities. MDIS emphasizes operational relevance, strategic competition, and the pathways that move innovation from concept to deployed capability.
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MDIS is now rescheduled to April 8-9, 2026, at the Grand Hall Ballroom at Crowne Plaza Union Station, located in the heart of downtown Indianapolis. Registration is now OPEN! Secure your spot below with a ticket to attend this year’s summit.
WHAT TO EXPECT
This year’s summit will feature keynote addresses, fireside conversations, and panel discussions led by the leaders shaping the future of defense—firmly rooted in America’s Heartland.
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Our full speaker lineup and session details will be announced soon - stay tuned for an agenda designed to inform, inspire, and drive impact.
STAY INFORMED
Stay informed on all the latest announcements, agenda updates, and breakout sessions. Click the button below to join our email list, or follow us on all our social platforms for the most up to date information.
REGISTRATION
Two days, one ticket. Every attendee must have their own registration; if attending in group, each member will need to register. Please note: there will be no onsite registration available.
SPEAKERS & PANELS
We’re excited to introduce an outstanding lineup of speakers for the Midwest Defense Innovation Summit (MDIS) 2025, happening October 15–16 at the Crowne Plaza Union Station in Indianapolis. This powerhouse group includes pioneers in defense, artificial intelligence, life and bio sciences, biosecurity, government and more, ready to deliver game-changing insights on AI, advanced manufacturing, and the future of national security.
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Join us to connect with these thought leaders and shape the future of defense innovation. Early bird registration is open.